Having determined that CXCR6-CXCL16 interaction is responsible for the integrin αvβ3 clustering, we investigated the role of CXCR6-CXCL16 axis in adhesion of LNCaP and PC3 cells to HBME cells, a model often used to study the role of integrin clustering on bone metastasis of PCa cells [18]. Here, CXCL16 is linked to posterior cortical atrophy.