In our study, increased phosphorylation of integrin -β3, activation of integrin pathway (αvβ3 pathway of integrin signaling) and increased αvβ3 clustering in PCa cells following CXCL16 treatment; and enhanced adhesion of PCa cells to HBME cells in presence of CXCL16 emphasizes that CXCR6-CXCL16 axis plays a crucial role in trafficking and homing of PCa cells. This evidence concerns the gene CXCR6 and posterior cortical atrophy.