analyzed 52 stage IV CRC patients according to the Glasgow Prognostic Score (GPS) and a panel of serum cytokines and chemokines, and found that patients with a high GPS score (both serum CRP level ≥10 mg/L and albumin level ≤3.5 g/dL) showed higher treatment toxicity and inferior prognosis. The gene discussed is CRP; the disease is colorectal carcinoma.