The study conducted by Kim-Howard and colleagues in 2010 on a very large population, constituted by 2366 SLE patients and 2931 unaffected controls with European ancestry, confirmed the link between the genetic variant rs1143679 of ITGAM and renal disorders as defined by the American College of Rheumatology (ACR) criteria (OR = 1.39) [26]. This evidence concerns the gene ITGAM and systemic lupus erythematosus.