In summary, our randomized trial in which sitagliptin was added to a CSII-based short-term intensive treatment in patients with newly diagnosed T2DM was very effective in improving glycemic excursions, glucose levels, GA, and β-cell function; additionally, a reduced incidence of hypoglycemia, a shorter time to achieve euglycemia, a significant reduction in the insulin dosage, and no weight gain were observed compared with CSII alone. This evidence concerns the gene INS and Hypoglycemia.