By using a different proteomic strategy, Kim and coworkers reported that increased plasma levels of glycated PEDF, apolipoprotein J precursor, hemopexin, immunoglobulin mu heavy chain, and immunoglobulin kappa chain correlated with poor glycaemic control in T2DM patients while glycated prekallikrein and complement factor C4B3 correlated with microalbuminuria and other glycated proteins such as hemopexin precursor, serine proteinase inhibitor, alpha-1-antitrypsin, and haptoglobin-related protein were associated with DN [88]. This evidence concerns the gene HPX and liver dysplastic nodule.