PTPRC and diabetes mellitus: Table 1 shows 40 IPA canonical pathways significantly affected by OVE diabetes arranged in 8 biological categories. Signaling pathways for hepatic fibrosis and leukocyte extravasation contained a large number of genes (26 and 27 genes, resp). altered in expression in OVE samples. This is consistent with the extensive fibrosis and CD45 positive cell infiltration of OVE kidneys (Figures 3 and 4).