Since anti-Ro/SSA is the most frequent autoantibody found in general population, but in most cases (60–70%) totally asymptomatic (114), an intriguing speculation is that by reducing the repolarization reserve anti-Ro/SSA may be silently involved as a predisposing factor in a number of “idiopathic” life-threatening arrhythmias, including drug-induced TdP, and sudden unexpected deaths occurring in apparently healthy people. This evidence concerns the gene TRIM21 and torsades de pointes.