However, it should be noted that one of these studies (37) was performed in SSc patients, who frequently display anti-Ro/SSA but at a low level (127), thus possibly not high enough for the threshold level required for QTc prolongation manifestation (29, 128); in another one (35), involving SLE patients, the authors used a cutoff for QTc prolongation (>500 ms) probably not adequate to detect the phenomenon in this setting, as previous studies consistently demonstrated that in the large majority of the anti-Ro/SSA-positive CTD patients with QTc prolongation values ranged from 440 to 500 ms. This evidence concerns the gene CALR and systemic sclerosis.