Moreover, using a combination of RAAS inhibitor drugs may also be helpful in offering a greater degree of renoprotection in subjects with DN. It was also been demonstrated that using a combination of ACEIs and aldosterone receptor blockers (ARBs) offers a greater degree of renoprotection in patients with diabetic nephropathy by the additive inhibition of NADPH oxidase [71]. The gene discussed is FMO5; the disease is liver dysplastic nodule.