FMO5 and liver dysplastic nodule: In addition, certain substances, such as triazolopyrimidine, GKT136901, and pyrazolopyridine dione derivatives, have been shown to have a variable degree of NADPH oxidase inhibiting activity, but their role in protecting podocyte injury against oxidative stress and improving the structural and functional impairments in DN has not been extensively studied thus far [60-62].