On the other hand, however, the increased lifespan associated with SIRT6 could imply that SIRT6 may promote tumor formation and, in fact, recently an increase of SIRT6 has been associated with enhancement of tumorigenicity of hepatocellular carcinoma cells in the presence of TGF-β1, H2O2, and HOCl [166]. The gene discussed is SIRT6; the disease is hepatocellular carcinoma.