ROS and HIF1α activation are responsible for the large metabolic reprogramming of cancer cells that requires other transcription factors such as Myc and proceeds with the overexpression of proteins such as glucose transporter 1 (GLUT1) for glucose uptake, glutaminase for glutamine usage, hexokinase II (HKII) for glycolysis, and carbonic anhydrase IX (CAIX) for control of intracellular pH, which assures the glucose and glutamine dependency and the fast growth of tumors [61, 78]. The gene discussed is MYC; the disease is cancer.