Moreover Liu et al. have recently reported the ability of Pter to inhibit JAK2/STAT3 signaling downregulating the expression of STAT3 target genes, including the antiapoptotic proteins Bcl-xL and Mcl-1, and leading to upregulation of mitochondrial apoptosis pathway-related proteins (Bax, Bak, cytosolic cytochrome c, and cleaved caspase 3) and cyclin-dependent kinase inhibitors such as p21 and p27 in osteosarcoma [87]. The gene discussed is STAT3; the disease is osteosarcoma.