COMT and cervical carcinoma: Table 4 showed that the association of the CYP1A1&COMT TC&HL genotypes leads to a higher risk for cervical cancer. The result of this association is, therefore, completely different from the result obtained when the polymorphisms were studied individually, namely, for COMT polymorphism. For protection model, we identified the CYP1A1&COMT TT&HL genotypes as a possible model that best fit on protection for cervical cancer (Table 4). In both models, CYP1A1&COMT TT&HL for risk or protection effects on cervical cancer were dependent on estradiol levels.