Knowing that estradiol stimulates the growth of HPV-positive cervical cancer cells [15] and as described by other authors, the levels of free estradiol are higher when the activity of COMT were low (COMT LL genotype) [30], contrary to CYP1A1. Noteworthy, most of cervical cancer women were perimenopausal, which is consistent with higher levels of estradiol, ultimately, within COMT polymorphism, affecting the formation of 2-methoxy-estradiol and immune system [31]. Here, COMT is linked to cervical cancer.