Our results are in line with the emerging evidence that methylation in the promoter region of CPT1A and specifically at the cg00574958 site is associated with several aspects of triglyceride biochemistry including associations with lipoprotein sub-fractions, hypertriglyceridemia, and the effect of lipid lowering drugs [22, 23, 61]. This evidence concerns the gene CPT1A and hypertriglyceridemia.