These loci map to an intron in FANCI, the GCOM1 and MYZAP promoter region, an intron in AHRR, and 147 bp 3′ of NBEAL2. The methylation differences at two of these loci, FANCI and NBEAL2, were also significant when considering only those carriers of the LH who had been diagnosed with either MDD or BD. This evidence concerns the gene AHRR and major depressive disorder.