TNFRSF11B and osteosarcoma: In studies conducted with a human osteosarcoma cell line, SaOS-2, or with the mouse osteoblastic cell line, MC3T3-E1, or bone marrow cells, it was observed that biosilica promoted osteogenesis, by increasing the expression of osteoprotegerin and bone morphogenetic protein 2, as well as the biomineralization [17–21].