Interestingly, aggression of cancer cells lacking ROBO1 receptor molecule was increased by CAFs expressing SLIT1 ligand [73], whereas RNAi SLIT1 increased hepatocyte growth factor-mediated cancer cell migration and invasion by upregulating CDC42 Rho GTPase activity [74], thus giving more insight into the inhibitory-stimulatory mechanism of CAFs that may depend on phenotypic differences of stromal cells and malignant epithelial cells. Here, ROBO1 is linked to cancer.