In our caf fed mice, administration of 0.037 mmol/kg/day of Ole and 0.025 mmol/kg/day of Ac-Ole, determined the following: (a) reduction in the body weight increase due to minor accumulation of fat in the abdominal adipose tissue, with unchanged food intake gain; (b) significant decrease of macroscopic and microscopic steatosis; (c) lower levels of serum lipids, with normalization of the levels of LDL-cholesterol; (d) correction of elevated glucose plasmatic levels without increase in insulin levels, associated with normal HOMA-IR. The gene discussed is INS; the disease is steatosis.