PROKR1 and chronic cystitis: Compared with those of the controls (n = 7), the PKR1 mRNA levels were significantly increased 4.02-fold (P < 0.01) and 2.07-fold (P < 0.01) in bladders with 48 h (n = 6) and 8 d (n = 6) CYP-induced cystitis, respectively, but not in the bladders with 4 h cystitis (n = 6) (Figure 1(b)).