As mentioned before HMGB1 interaction with RAGE activates NF-κB pathway sustaining inflammation; Wang et al. tried to target NF-κB with an inhibitor on mice with COPD obtaining a downregulation of HMGB1 in lung tissue adding more elements in a blockage strategy of inflammation in an early phase of COPD [19]. This evidence concerns the gene HMGB1 and chronic obstructive pulmonary disease.