Epidemiological studies reported that the development and progression of TB in human is strongly associated with gene polymorphism; up to now, gene polymorphisms of vitamin D receptor, SLC11A1, tumor necrosis factor-alpha, Toll-like receptor 2, and monocyte chemoattractant protein-1 have been identified to be associated with the susceptibility to TB [6–9]. The gene discussed is TNF; the disease is tuberculosis.