Flow cytometry analysis showed that the CD11b+GR-1+ MDSCs in the AD mice were infiltrated much more than that in the normal mice into the colonic tissues (5.283% ± 0.195% vs. 0.0128% ± 0.0028%, P < 0.001) (Fig. 3A and 3B). The gene discussed is ITGAM; the disease is Alzheimer disease.