FZD8 and carcinoma: Previously, we developed a small RNA delivery system using tetraethylenepentamine-based polycation liposomes (TEPA-PCL) [6,7,8] and demonstrated that miR-499/TEPA-PCL reduces the secretion of VEGF and the production of other pro-angiogenic factors, e.g., CnAα and frizzled family receptor 8 (FZD8), in Colon 26 NL-17 mouse carcinoma cells [5].