Anthracyclines, quinone-based chemotherapeutics that are the backbone of chemotherapy regimens commonly used to treat AML, are substrates of the ATP-binding cassette protein drug efflux pumps ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein), which are expressed on AML cells and other cancer cells [24]. The gene discussed is ABCB5; the disease is acute myeloid leukemia.