EGCG supplementation also enhanced the expression of UCP2 in the liver and stearoyl-CoA desatuase-1 (SCD1), a key enzyme in fatty acid synthesis [157], in epididymal white adipose tissue, which confirms that green tea EGCG induces energy expenditure and inhibits fatty acid synthesis in order to attenuate obesity and adiposity [135]. This evidence concerns the gene UCP2 and obesity due to melanocortin 4 receptor deficiency.