Therefore, the objective of this study was to evaluate the anti-hepatic fibrosis effect of CPhGs and the correpsnding monomers (echinacoside and acteoside) by inhibiting HSC activation, blocking the conduction of signaling pathways in TGF-β1/smad, and examine its in vitro hepatoprotective activity. The gene discussed is TGFB1; the disease is Hepatic fibrosis.