Proline-rich transmembrane protein 2 (PRRT2) is encoded by a gene that has been shown recently to be the single causative gene for a group of paroxysmal syndromes of infancy, including benign familial infantile seizures, infantile convulsion choreoathetosis, migraine, hemiplegic migraine, and paroxysmal kinesigenic dyskinesia/choreoathetosis. This evidence concerns the gene PRRT2 and familial or sporadic hemiplegic migraine.