RPRM and breast cancer: Interestingly, RPRM is located at chromosome 2q23.3, a locus that often has allelic imbalance in BC [27]; nevertheless, we observed that loss or repression of mRNA expression was restored by 5′Aza-dC treatment, concluding that there is probably no allelic imbalance of 2q23 involved in loss of RPRM mRNA expression in these two cell lines.