Two observations were noteworthy: (i) TB and TM shared many specific DHSs that were absent in TN, highlighting the similarity between the recently activated proliferating TB and the quiescent primary TM; (ii) we reproducibly observed global enrichment of the same population of DHSs in TB compared to TN for both CD4 and CD8 T cells when all the data, including independent replicates of the CD4 TN and TB samples, were plotted using the same ranking as used for the original CD4 TN and TB data shown in Fig 3B (Fig EV2A). This evidence concerns the gene CD4 and tuberculosis.