Analysis of tissue sections harvested from the ear, trachea, and hindlimb demonstrated a 2–3 fold increase in the number of infiltrating CD45+ cells (a pan-leukocyte marker) within a 50 μm radius of tissue capillary lymphatic vessels (LYVE-1+), suggesting that perilymphatic inflammation in obesity is a systemic phenomenon (Fig. 1a–f). The gene discussed is PTPRC; the disease is obesity due to melanocortin 4 receptor deficiency.