Subgroup analysis by the smoking status showed that SSTR2 promoter hypermethylation was associated with the risk of laryngeal cancer in the patients with and without smoking behaviors (Figure 3a, smokers: 5.46 ± 4.94 % versus 3.88 ± 2.13 %, P = 0.013, adjusted P = 0.021; non-smokers: 7.56 ± 5.78 versus 3.87 ± 1.87, P = 0.033, adjusted P = 0.033). Here, SSTR2 is linked to laryngeal carcinoma.