Likewise the National Comprehensive Cancer Network (NCCN) Guideline for AML incorporates CN-AML with NPM1 mutation or isolated CEBPA mutation in the absence of FLT3-ITD in the better-risk status category, whilst CN-AML with FLT3-ITD mutation is considered poor-risk [8]. This evidence concerns the gene FLT3 and acute myeloid leukemia.