NPM1 and acute myeloid leukemia: The genetic aberrations can be grouped under nine categories defined according to biological function and a putative role in AML pathogenesis, namely transcription factor fusions, gene encoding nucleophosmin (NPM1), tumor suppressor genes, DNA methylation-related genes (DNMT3A, IDH1, IDH2 and TET2), activated signaling genes, chromatin modifying genes, myeloid transcription factor genes, cohesin complex genes and spliceosome complex genes [10].