NFATc2 likely opposes the action of NFATc1, NFATc3, and NFATc4 in colon cancer cells as those tumors lacking NFATc2 expression most likely had a more aggressive clinical course driven in part by the unopposed actions of NFATc1, NFATc3, and NFATc4. The gene discussed is NFATC1; the disease is malignant colon neoplasm.