In T lymphocyte/pulsed DC co-cultures, T-cell production of IFN-γ was likely supported by IL-12p70, a potent inducer of TH1 polarization, whose secretion was high on day 1 and 7 of co-culture; both cytokines have been shown to have a variety of both direct and indirect effects on tumours and to be critical for tumour rejection in a number of models [40,41,42]. Here, IFNG is linked to neoplasm.