Numerous studies have linked MBL deficiency with increased susceptibility to a variety of infectious and autoimmune diseases (reviewed in (Bjarnadottir and Ludviksson 2010; Dommett et al. 2006; Eisen and Minchinton 2003; Kilpatrick 2002; Thiel et al. 2006; Worthley et al. 2005). This evidence concerns the gene MBL2 and hyperinsulinemic hypoglycemia, familial, 4.