In fact, severalpublications have reported the deleterious impact of obesity and of stress in feedinghabits, blood and brain inflammation, and in neurodegeneration.1, 26 For instance,white-adipose tissue itself produces adipokines,27 interleukins and leptin (an adipokine regulating foodintake through dopamine pathway).28 Hence,high levels of white-adipose tissue will secrete higher levels of adipokines directlymodulating feeding habits and the inflammatory profile. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.