Several studies identified mammalian TOR (mTOR) as a key regulator of cardiac hypertrophy; for example, the mTOR inhibitor rapamycin prevents heart-weight gain in an overload model of hypertrophy5 and blocks cardiomyocyte size increases induced by AngII6 and phenylephrine7, likely by inhibiting protein synthesis7. The gene discussed is MTOR; the disease is cardiac hypertrophy.