In the miRNA regulatory network, miR-34c and its target genes including TP53, CCND1, BCL2, CDK6 and MET are shown to play important roles in NPC, and the PI3K/AKT/mTOR signaling is regarded as a significant function pathway mediated by miR-34c. The gene discussed is AKT1; the disease is nasopharyngeal carcinoma.