After bioinformatics analysis and literature review, we identify miR-34c as an important partner in NPC tumorigenesis, and propose that miR-34c-target genes network (including CCND1, TP53, BCL2, CDK6, MET) should be critical in mediating NPC cellular proliferation, migration and invasion. The gene discussed is CDK6; the disease is nasopharyngeal carcinoma.