CTBP2 and coronary artery disorder: For CHD, we used a quantitative measure of hip conformation—the Norberg angle (NA)—in 921 dogs across 69 breeds and found an association reaching genome-wide significance on chromosome (CFA) 28 (P=4.9 × 10−8, β=0.07, Wald test) in the gene CTBP2 (Fig. 1a).