In addition, the combination of several factors (use of AcMNPV GP64 signal sequence, codons optimized to insect cells, and baculovirus knockout for chitinase and cathepsin) described in the current manuscript has a wide application in the field of recombinant protein production, useful for future studies on prophylactic and therapeutic interventions in cancer, inflammatory and infectious diseases in dogs. The gene discussed is CTSS; the disease is infectious disease.