Repressive chromatin marks H3K9me3 and H3K27me3 were unaffected due to DNMT3L expression but the levels of the active histone marks H3K4me3, H3K4me2 and H3k36me3 were dramatically reduced in tumor bearing G5 3rd instar larvae (Fig. 8C). The gene discussed is DNMT3L; the disease is neoplasm.