Our results are more in agreement with those of Garcia et al. A recent study of CD8+ T cell responses observed that individuals with neuroinvasive WNV infection had WNV-specific CD8+ T cells that were predominately monofunctional, but T cells from subjects with neuroinvasive disease were shown to have significantly increased CD107a, implying greater cytolytic potential [30]. Here, CD8A is linked to glycogen storage disease VI.