To investigate this further we combine systemic administration of IL-1 with a remote filament model of middle cerebral artery occlusion (MCAo) (Burrows et al., 2015), using two-dimensional optical imaging spectroscopy (2D-OIS), to confirm the effects of IL-1 on cortical oxyhaemoglobin dynamics during reperfusion after stroke in mice. This evidence concerns the gene IL1B and Stroke.