TP53 and infection: In this study, Robbiani et al. showed that mice repeatedly infected with this species of malaria parasite develop prolonged expansion of GCs in which the B cells undergo rapid expansion and express AID—exactly what was seen in the human infection with P. falciparum. These authors went on to show that this resulted in the accumulation of widespread DNA damage in the GC cells, including translocations, which was associated with subsequent lymphoma development, but only when expressed on a p53-null background.