STS and cancer: Moreover, a completely different response was observed for lactate dehydrogenase (LDH, Fig. 3F) and for the rate-limiting steps of glycolysis catalysed by phosphofructokinase (PFK) and pyruvate kinase (PK) (Fig. 3G,H): the catalytic function of these enzymes was selectively impaired by STS being virtually not responsive to MTF (Supplementary Figure 3F-H) in both cancer models.