Larsen et al.19 reported that IL-1β stimulated the time-dependent induction of endogenous Gadd45b in rat insulinoma INS-1E cells and rat islets and Gadd45b overexpression can significantly reduce apoptosis induced by IL-1β in INS-1E cells and in mouse beta-TC3 cells. This evidence concerns the gene IL1B and pancreatic insulinoma.