Given the recent studies of a number of animal models of podocyte injury and glomerular diseases implicating GADD45B in podocyte injury, we now have utilized zebrafish models and cultured human podocytes to determine that the induction of GADD45B is an early response to podocyte injury that regulates podocyte apoptosis in response to ROS through the activation of p38 MAPK pathway. Here, GADD45B is linked to glomerular disorder.