To determine whether myricetin and spinacine re-sensitize SiHa cells to TRAIL-induced apoptosis by specifically blocking the binding of E6 to caspase 8, we compared responses in the HPV+ SiHa cells with those from the HPV− human cervical carcinoma cell, C33A, as these cells do not express E6. Here, CASP8 is linked to cervical carcinoma.