IGF1 and cardiovascular disorder: In addition, IGF-1 levels in childhood and adolescence are predictive of IGF-1 levels in adulthood (Sandhu et al. 2006), and lower levels of IGF-1 in adults have been associated with diabetes, cardiovascular diseases, and an increased risk of mortality (Burgers et al. 2011; Ceda et al. 2005; Vaessen et al. 2001).