TOP2A but not TOP2B is degraded in a cell cycle dependent manner in a way that appears to involve the ubiquitin–proteasome pathway [22] and TOP2A degradation has also been observed in a number of conditions that generate cellular stress, including adenovirus infection, glucose starvation and oxidative stress [23], [24], [25], [26], [27]. Here, TOP2A is linked to adenoviridae infectious disease.