HMGB1 like IL-1α is found in CF sputa (Rowe et al., 2008; Colombo et al., 2011), whereas S100A9 is a part of Calprotectin, a complex described as the Cystic Fibrosis protein in 1973 (Wilson et al., 1973). The gene discussed is IL1A; the disease is cystic fibrosis.