Massive generalized edema (anasarca) is common, especially in children with primary minimal change disease (MCD) and serves as the main clinical justification for hospital admission for “diuretic management.” In such children, the selective loss of large amounts of albumin in the urine leads to hypoalbuminemia and decreased plasma oncotic pressure favoring fluid sequestration in the interstitial fluid compartment, and secondarily triggers renal Na+ and fluid retention so as to preserve intravascular volume and blood pressure, hence preventing an “underfill” state. This evidence concerns the gene ALB and Hypoalbuminemia.