In addition, the effect of TLR5 ligand on enteric bacterial infections might depend on the type of flagellin used as the previous report used Salmonella flagellin to fight against Salmonella infection (Vijay-Kumar et al., 2008) and we did not see the protective effect of flagellin on a different bacterial pathogen, Y. enterocolitica. Here, TLR5 is linked to Salmonella Infections.